diff --git a/Changelog.md b/Changelog.md
index 4fe1374..2bc3653 100644
--- a/Changelog.md
+++ b/Changelog.md
@@ -1,6 +1,7 @@
 # Version 0.10.2 (UPCOMING)
 
 * Avoid publicly exporting SQLite constants multiple times from libsqlite3-sys.
+* Adds `FromSql` and `ToSql` impls for `isize`. Documents why `usize` and `u64` are not included.
 
 # Version 0.10.1 (2017-03-03)
 
diff --git a/src/types/from_sql.rs b/src/types/from_sql.rs
index 415ff27..ab79750 100644
--- a/src/types/from_sql.rs
+++ b/src/types/from_sql.rs
@@ -49,6 +49,14 @@ impl Error for FromSqlError {
 pub type FromSqlResult<T> = Result<T, FromSqlError>;
 
 /// A trait for types that can be created from a SQLite value.
+///
+/// Note that `FromSql` and `ToSql` are defined for most integral types, but not `u64` or `usize`.
+/// This is intentional; SQLite returns integers as signed 64-bit values, which cannot fully
+/// represent the range of these types. Rusqlite would have to decide how to handle negative
+/// values: return an error or reinterpret as a very large postive numbers, neither of which is
+/// guaranteed to be correct for everyone. Callers can work around this by fetching values as i64
+/// and then doing the interpretation themselves or by defining a newtype and implementing
+/// `FromSql`/`ToSql` for it.
 pub trait FromSql: Sized {
     fn column_result(value: ValueRef) -> FromSqlResult<Self>;
 }
@@ -72,6 +80,7 @@ macro_rules! from_sql_integral(
 from_sql_integral!(i8);
 from_sql_integral!(i16);
 from_sql_integral!(i32);
+from_sql_integral!(isize);
 from_sql_integral!(u8);
 from_sql_integral!(u16);
 from_sql_integral!(u32);
diff --git a/src/types/to_sql.rs b/src/types/to_sql.rs
index 0e4d754..3d4df7f 100644
--- a/src/types/to_sql.rs
+++ b/src/types/to_sql.rs
@@ -74,6 +74,7 @@ to_sql_self!(i8);
 to_sql_self!(i16);
 to_sql_self!(i32);
 to_sql_self!(i64);
+to_sql_self!(isize);
 to_sql_self!(u8);
 to_sql_self!(u16);
 to_sql_self!(u32);
diff --git a/src/types/value.rs b/src/types/value.rs
index e192826..65dfc94 100644
--- a/src/types/value.rs
+++ b/src/types/value.rs
@@ -43,6 +43,7 @@ macro_rules! from_i64(
 from_i64!(i8);
 from_i64!(i16);
 from_i64!(i32);
+from_i64!(isize);
 from_i64!(u8);
 from_i64!(u16);
 from_i64!(u32);