diff --git a/src/inner_connection.rs b/src/inner_connection.rs
index 9e291c9..33245c8 100644
--- a/src/inner_connection.rs
+++ b/src/inner_connection.rs
@@ -59,7 +59,11 @@ impl InnerConnection {
         }
     }
 
-    pub fn open_with_flags(c_path: &CString, flags: OpenFlags) -> Result<InnerConnection> {
+    pub fn open_with_flags(
+        c_path: &CString,
+        flags: OpenFlags,
+        vfs: Option<&CString>,
+    ) -> Result<InnerConnection> {
         #[cfg(not(feature = "bundled"))]
         ensure_valid_sqlite_version();
         ensure_safe_sqlite_threading_mode()?;
@@ -79,10 +83,14 @@ impl InnerConnection {
             ));
         }
 
+        let z_vfs = match vfs {
+            Some(c_vfs) => c_vfs.as_ptr(),
+            None => ptr::null(),
+        };
+
         unsafe {
             let mut db = MaybeUninit::uninit();
-            let r =
-                ffi::sqlite3_open_v2(c_path.as_ptr(), db.as_mut_ptr(), flags.bits(), ptr::null());
+            let r = ffi::sqlite3_open_v2(c_path.as_ptr(), db.as_mut_ptr(), flags.bits(), z_vfs);
             let db: *mut ffi::sqlite3 = db.assume_init();
             if r != ffi::SQLITE_OK {
                 let e = if db.is_null() {
diff --git a/src/lib.rs b/src/lib.rs
index 775110e..30f457d 100644
--- a/src/lib.rs
+++ b/src/lib.rs
@@ -371,7 +371,31 @@ impl Connection {
     /// string or if the underlying SQLite open call fails.
     pub fn open_with_flags<P: AsRef<Path>>(path: P, flags: OpenFlags) -> Result<Connection> {
         let c_path = path_to_cstring(path.as_ref())?;
-        InnerConnection::open_with_flags(&c_path, flags).map(|db| Connection {
+        InnerConnection::open_with_flags(&c_path, flags, None).map(|db| Connection {
+            db: RefCell::new(db),
+            cache: StatementCache::with_capacity(STATEMENT_CACHE_DEFAULT_CAPACITY),
+            path: Some(path.as_ref().to_path_buf()),
+        })
+    }
+
+    /// Open a new connection to a SQLite database using the specific flags and
+    /// vfs name.
+    ///
+    /// [Database Connection](http://www.sqlite.org/c3ref/open.html) for a description of valid
+    /// flag combinations.
+    ///
+    /// # Failure
+    ///
+    /// Will return `Err` if either `path` or `vfs` cannot be converted to a
+    /// C-compatible string or if the underlying SQLite open call fails.
+    pub fn open_with_flags_and_vfs<P: AsRef<Path>>(
+        path: P,
+        flags: OpenFlags,
+        vfs: &str,
+    ) -> Result<Connection> {
+        let c_path = path_to_cstring(path.as_ref())?;
+        let c_vfs = str_to_cstring(vfs)?;
+        InnerConnection::open_with_flags(&c_path, flags, Some(&c_vfs)).map(|db| Connection {
             db: RefCell::new(db),
             cache: StatementCache::with_capacity(STATEMENT_CACHE_DEFAULT_CAPACITY),
             path: Some(path.as_ref().to_path_buf()),
@@ -387,12 +411,21 @@ impl Connection {
     ///
     /// Will return `Err` if the underlying SQLite open call fails.
     pub fn open_in_memory_with_flags(flags: OpenFlags) -> Result<Connection> {
-        let c_memory = str_to_cstring(":memory:")?;
-        InnerConnection::open_with_flags(&c_memory, flags).map(|db| Connection {
-            db: RefCell::new(db),
-            cache: StatementCache::with_capacity(STATEMENT_CACHE_DEFAULT_CAPACITY),
-            path: None,
-        })
+        Connection::open_with_flags(":memory:", flags)
+    }
+
+    /// Open a new connection to an in-memory SQLite database using the specific
+    /// flags and vfs name.
+    ///
+    /// [Database Connection](http://www.sqlite.org/c3ref/open.html) for a description of valid
+    /// flag combinations.
+    ///
+    /// # Failure
+    ///
+    /// Will return `Err` if vfs` cannot be converted to a C-compatible
+    /// string or if the underlying SQLite open call fails.
+    pub fn open_in_memory_with_flags_and_vfs(flags: OpenFlags, vfs: &str) -> Result<Connection> {
+        Connection::open_with_flags_and_vfs(":memory:", flags, vfs)
     }
 
     /// Convenience method to run multiple SQL statements (that cannot take any